"Mayo," "Mayo Clinic," "MayoClinic.org," "Mayo Clinic Healthy Living," and the triple-shield Mayo Clinic logo are trademarks of Mayo Foundation for Medical Education and Research. Avoid or Use Alternate Drug. Effect of interaction is not clear, use caution. imatinib will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. According to the FDA, drugs that may interact with this medication include the following. doxepin and trimipramine both decrease cholinergic effects/transmission. In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. Either increases effects of the other by pharmacodynamic synergism. Tips Either increases levels of the other by pharmacodynamic synergism. Be especially watchful for these symptoms if a new antidepressant is started or when the dose is changed.Get medical help right away if you have any very serious side effects, including: eye pain/swelling/redness, widened pupils, vision changes (such as seeing rainbows around lights at night, blurred vision).A very serious allergic reaction to this drug is rare. Other (see comment). Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. doxepin and bedaquiline both increase QTc interval. Use Caution/Monitor. Use Caution/Monitor. Other (see comment). doxepin increases effects of saxagliptin by pharmacodynamic synergism. Modify Therapy/Monitor Closely. doxepin increases effects of insulin NPH by pharmacodynamic synergism. Monitor Closely (1)doxepin and cocaine topical both increase serotonin levels. Avoid or Use Alternate Drug. Avoid or Use Alternate Drug. Confusion, extrapyramidal symptoms (EPS), dizziness, paresthesia, Orthostatic hypotension, ECG changes, tachycardia, In short-term studies, antidepressants increased the risk of suicidal thinking and behavior in children, adolescents, and young adults (<24 years) taking antidepressants for major depressive disorders and other psychiatric illnesses, This increase was not seen in patients >24 years; a slight decrease in suicidal thinking was seen in adults >65 years, In children and young adults, risks must be weighed against the benefits of taking antidepressants, Patients should be monitored closely for changes in behavior, clinical worsening, and suicidal tendencies; this should be done during initial 1-2 months of therapy and dosage adjustments, The patients family should communicate any abrupt changes in behavior to the healthcare provider, Worsening behavior and suicidal tendencies that are not part of the presenting symptoms may require discontinuation of therapy, This drug is not approved for use in pediatric patients, Use caution in BPH, urinary retention, decreased GI motility, hyperthyroidism, brain tumor, diabetes, hepatic impairment, cardiovascular disease, mania/hypomania, respiratory disease, and seizure disorders, Clinical worsening and suicidal ideation may occur despite medication in adolescents and young adults (aged 18-24 years), Risk of mydriasis; may trigger angle closure attack in patients with angle closure glaucoma with anatomically narrow angles without a patent iridectomy, CNS depressant; can impair alertness and motor coordination; avoid use with other CNS depressants (eg, alcohol), Overdose may cause EKG QRS widening and risk of dysrhythmias, Protect capsules and oral concentrate from direct sunlight, Prescriptions should be written for smallest quantity consistent with good patient care; patient's family or caregiver should alert healthcare professional about emergence of suicidality and related behaviors including agitation, panic attacks, irritability, impulsivity, mania, and insomnia or if worsening depression or psychosis occurs, Anticholinergic effects including blurred vision, urinary retention, xerostomia, and constipation may occur, Neuropsychiatric symptoms may occur unpredictably including anxiety and psychosis, Bone fracture reported with use of antidepressant therapy; consider possibility of fracture if patient presents with unexplained bone pain, joint tenderness, bruising or swelling, May cause orthostatic hypotension; use caution in patients at risk of this effect or that may not tolerate hypotensive episodes (eg, hypovolemia, cardiovascular or cerebrovascular disease and others), Sleep related activities including sleep driving, eating food, cooking, making phone calls reported; discontinue therapy if patient reports sleep-related episodes, Possibility of EPS and neuroleptic malignant syndrome (NMS), May cause confusion in the elderly; avoid doses >6 mg/day, Available data from published epidemiologic studies and postmarketing reports have not established increased risk of major birth defects or miscarriage; there are risks of poor neonatal adaptation with exposure to drug during pregnancy, Data from published report presence of drug and metabolite in human milk; there are reports of excess sedation, respiratory depression, poor sucking and swallowing, and hypotonia in breastfed infants exposed to drug, There are no data on effects of drug on milk production; because of potential for serious adverse reactions, including excess sedation and respiratory depression in a breastfed infant, advise patients that breastfeeding is not recommended during therapy, Infants exposed to drug through breast milk should be monitored for excess sedation, respiratory depression and hypotonia. Either increases toxicity of the other by serotonin levels. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. Monitor Closely (1)dantrolene and doxepin both increase sedation. Comment: Risk of neurotoxicity in geriatric pts. Modify Therapy/Monitor Closely. Monitor Closely (2)asenapine will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor. Monitor Closely (1)carisoprodol and doxepin both increase sedation. Serious - Use Alternative (1)doxepin and moxifloxacin both increase QTc interval. Avoid or Use Alternate Drug. Monitor Closely (1)scopolamine and doxepin both decrease cholinergic effects/transmission. Avoid or Use Alternate Drug. Use Caution/Monitor. Comparable efficacy between the compounds was found across the 13-week study. Sign up for free, and stay up to date on research advancements, health tips and current health topics, like COVID-19, plus expertise on managing health. Either increases levels of the other by decreasing metabolism. privacy practices. However, cyclic antidepressants may be a good option for some people. Avoid or Use Alternate Drug. Minor/Significance Unknown. Use Caution/Monitor. Patients treated with selinexor may experience neurological toxicities. Avoid or Use Alternate Drug. Minor (1)ethinylestradiol, doxepin. Minor/Significance Unknown. liotrix increases effects of doxepin by Other (see comment). Use Caution/Monitor. Modify Therapy/Monitor Closely. Effect of interaction is not clear, use caution. Avoid or Use Alternate Drug.Minor (2)doxepin, chlorpromazine. Sometimes the foods we eat and the beverages we drink can also interact with our medications. Minor (1)hydroxyprogesterone caproate, doxepin. doxepin and ketoconazole both increase QTc interval. The information provided here is for informational purposes only. Modify Therapy/Monitor Closely. Modify Therapy/Monitor Closely. Avoid coadministration of sensitive CYP2D6 substrates with givosiran. Avoid or Use Alternate Drug.fluoxetine and doxepin both increase serotonin levels. Effect of interaction is not clear, use caution. Avoid or Use Alternate Drug. Use Caution/Monitor.belladonna and opium and doxepin both increase sedation. doxepin and 5-HTP both increase serotonin levels. doxepin and dextroamphetamine both increase serotonin levels. It is not known how this medication improves sleep, though it may be due to blocking histamine receptors. Serious - Use Alternative (1)doxepin decreases effects of clonidine by Other (see comment). Use Caution/Monitor. Use Caution/Monitor. Due to the poor systemic absorption of ipratropium, interaction unlikely at regularly recommended dosages. levorphanol and doxepin both increase sedation. Monitor Closely (1)homatropine and doxepin both decrease cholinergic effects/transmission. Monitor Closely (1)osilodrostat and doxepin both increase QTc interval. the unsubscribe link in the e-mail. risperidone and doxepin both increase sedation. Monitor Closely (1)doxepin, phenylephrine ophthalmic. ethinylestradiol, doxepin. Avoid or Use Alternate Drug. Amitriptyline (prescribing information). Serious - Use Alternative (1)linezolid and doxepin both increase serotonin levels. Medications that cause weight gain and alternatives in Canada: a narrative review. Monitor Closely (1)meclizine and doxepin both decrease cholinergic effects/transmission. ketamine and doxepin both increase sedation. Avoid or Use Alternate Drug. Use Caution/Monitor. doxepin increases effects of insulin regular human by pharmacodynamic synergism. doxepin and fluoxetine both increase QTc interval. Coadministration may result in profound sedation, respiratory depression, coma, and/or death. Minor/Significance Unknown. doxepin decreases effects of guanfacine by Other (see comment). Coadministration of glycopyrronium tosylate topical with other anticholinergic medications may result in additive anticholinergic adverse effects. doxepin, sodium oxybate. Serious - Use Alternative (1)doxepin, serdexmethylphenidate/dexmethylphenidate. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. All rights reserved. Either increases effects of the other by serotonin levels. Monitor Closely (1)tiotropium and doxepin both decrease cholinergic effects/transmission. lemborexant, doxepin. Avoid or Use Alternate Drug. Monitor Closely (1)lorazepam and doxepin both increase sedation. Linezolid may increase serotonin as a result of MAO-A inhibition. Use Caution/Monitor. Mechanism: unspecified interaction mechanism. Safety and efficacy have not been established. propofol, doxepin. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Other (see comment). With therapeutic doses of TCAs, barbiturates increase metabolism and decrease blood concentrations of TCAs. An official website of the United States government. Avoid or Use Alternate Drug. Monitor Closely (1)trihexyphenidyl and doxepin both decrease cholinergic effects/transmission. Risk of arrhythmias or hypotension. Cyclic antidepressants also affect other chemical messengers, which can lead to a number of side effects. Contraindicated. commonly, these are "preferred" (on formulary) brand drugs. Use Caution/Monitor.Serious - Use Alternative (1)granisetron, doxepin. Doxepin is a psychotropic agent with antidepressant and anxiolytic properties. buprenorphine buccal and doxepin both increase QTc interval. Either increases levels of the other by pharmacodynamic synergism. Monitor Closely (1)meperidine and doxepin both increase sedation. Check for more interactions with the Drug Interaction Checker Check Now Drug Interaction Categories Effect of interaction is not clear, use caution. Accessed Aug. 13, 2019. Either increases toxicity of the other by serotonin levels. amiodarone will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. To help you remember, take it at the same time each day.Tell your doctor if your condition lasts or gets worse after 7-10 days. Otherwise, call a poison control center right away. Effect of interaction is not clear, use caution. Effect of interaction is not clear, use caution. Avoid or Use Alternate Drug. Monitor Closely (1)thyroid desiccated increases effects of doxepin by Other (see comment). Minor/Significance Unknown. Avoid or Use Alternate Drug. When choosing an antidepressant, your doctor takes into account your symptoms, any health problems, other medications you take, and what's worked for you in the past. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Drugs that prolong the QTc interval and may potentiate the effects of beta2 agonists on the cardiovascular system; increased risk of ventricular arrhythmias. Minor (1)estrogens esterified, doxepin. stiripentol, doxepin. Monitor Closely (1)doxepin and gilteritinib both increase QTc interval. Contraindicated. Consult your healthcare professional (e.g., doctor or pharmacist) for more in formation. Minor/Significance Unknown. amobarbital and doxepin both increase sedation. doxepin oral brand names and other generic formulations include: bupropion hcl oral will increase the level or effect of doxepin oral by altering drug metabolism. Either increases levels of the other by decreasing metabolism. Monitor Closely (1)eletriptan and doxepin both increase serotonin levels. Use Caution/Monitor. Effect of interaction is not clear, use caution. Use Caution/Monitor. Use Caution/Monitor. doxepin and propafenone both increase QTc interval. Contraindicated (1)doxepin and disopyramide both increase QTc interval. Combination is contraindicated within 2 weeks of MAOI use. If you are a Mayo Clinic patient, this could Use Caution/Monitor. Citalopram may increase TCA levels. Moderately clinically significant. Severe Interactions These medications are not usually taken together. tapentadol and doxepin both increase sedation. Avoid or Use Alternate Drug. Avoid or Use Alternate Drug. Minor/Significance Unknown. Avoid or Use Alternate Drug. tucatinib will increase the level or effect of doxepin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Use combination with caution. Modify Therapy/Monitor Closely. In some cases, where available, results of special blood tests may offer clues about how your body may respond to a specific antidepressant. hydrocodone, doxepin. Limit dosages and durations to the minimum required. Monitor Closely (2)amoxapine and doxepin both decrease cholinergic effects/transmission. Minor/Significance Unknown. doxepin and alfuzosin both increase QTc interval. Use Caution/Monitor. All rights reserved. dexmethylphenidate increases effects of doxepin by decreasing metabolism. Minor/Significance Unknown. Effect of interaction is not clear, use caution. dextromoramide and doxepin both increase sedation. Monitor Closely (1)celecoxib will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor.doxepin and tramadol both increase serotonin levels. Use Caution/Monitor. Migraines and gastrointestinal problems: Is there a link? Minor/Significance Unknown. Monitor Closely (1)pilocarpine increases and doxepin decreases cholinergic effects/transmission. Avoid or Use Alternate Drug. doxepin and citalopram both increase QTc interval. doxepin increases levels of glycopyrrolate inhaled by unknown mechanism. doxepin, epinephrine racemic. . Minor/Significance Unknown. Use Caution/Monitor. Use Caution/Monitor. Monitor Closely (1)cinnarizine and doxepin both increase sedation. View the formulary and any restrictions for each plan. Effect of interaction is not clear, use caution. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Use Caution/Monitor. conjugated estrogens, vaginal, doxepin. Monitor Closely (1)butabarbital and doxepin both increase sedation. Monitor Closely (1)ritonavir will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Avoid or Use Alternate Drug. Minor/Significance Unknown. Additive anticholinergic effects.doxepin, trifluoperazine. Effect of interaction is not clear, use caution. Avoid or Use Alternate Drug. Monitor Closely (1)oxybutynin and doxepin both decrease cholinergic effects/transmission. Use Caution/Monitor. Effect of interaction is not clear, use caution. Serious - Use Alternative (1)dacomitinib will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Modify Therapy/Monitor Closely. Use Caution/Monitor. mefloquine increases toxicity of doxepin by QTc interval. doxepin and octreotide (Antidote) both increase QTc interval. Use Caution/Monitor. Other (see comment). Other (see comment). verapamil increases levels of doxepin by decreasing metabolism. Minor/Significance Unknown. sevoflurane and doxepin both increase sedation. doxepin, prochlorperazine. However, cyclic antidepressants may be a good option for some people. Assess need to reduce dose of CYP2D6-metabolized drug. mirabegron will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Other (see comment). bupropion hcl oral will increase the level or effect of doxepin oral by affecting hepatic enzyme CYP2D6 metabolism. Effect of interaction is not clear, use caution. doxepin and vilanterol/fluticasone furoate inhaled both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. affecting hepatic/intestinal enzyme CYP3A4 metabolism. 9 It is a tertiary amine that can be presented as (E) and (Z) stereoisomers with the (Z) stereoisomer corresponding to cidoxepin.Doxepin commonly produces a 5:1 (E):(Z) racemic mixture. doxepin and nortriptyline both increase QTc interval. Either increases effects of the other by pharmacodynamic synergism. Monitor Closely (1)opium tincture and doxepin both increase sedation. Avoid or Use Alternate Drug. Other (see comment). Minor/Significance Unknown. Avoid or Use Alternate Drug. diphenhydramine will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor.Minor (1)primidone, doxepin. Hypothyroidism: Can calcium supplements interfere with treatment? suvorexant and doxepin both increase sedation. Use Caution/Monitor. Monitor Closely (1)flurazepam and doxepin both increase sedation. Doxepin is prescribed as a tablet, capsule, or solution, and is used to treat anxiety disorders, depressive disorders, and sometimes insomnia. Use Caution/Monitor. Use Caution/Monitor. Avoid or Use Alternate Drug. Sometimes certain medications can increase the risk of negative side effects for patients with certain diseases or other medical conditions. Modify Therapy/Monitor Closely.doxepin increases toxicity of oliceridine by Other (see comment). Monitor for hypertension with concomitant use.doxepin and ozanimod both increase QTc interval. Minor/Significance Unknown. Concomitant therapy should be discontinued immediately if signs or symptoms of serotonin syndrome emerge and supportive symptomatic treatment should be initiated. Minor/Significance Unknown. Serious - Use Alternative (2)sertraline and doxepin both increase serotonin levels. Avoid or Use Alternate Drug. We comply with the HONcode standard for trustworthy health information. This report displays the potential drug interactions for the following 2 drugs: Applies to: Wellbutrin (bupropion) and doxepin. Risk of arrhythmias or hypotension. Avoid or Use Alternate Drug. Use Caution/Monitor. Individual plans may vary Use Caution/Monitor. Avoid coadministration of fexinidazole with drugs known to block potassium channels or prolong QT interval. A different medication may be necessary in those cases.Usually, insomnia is temporary and requires sleep medications only for a short time. Avoid or Use Alternate Drug.amoxapine and doxepin both increase serotonin levels. Monitor Closely (2)doxepin and protriptyline both decrease cholinergic effects/transmission. Monitor Closely (1)hyoscyamine spray and doxepin both decrease cholinergic effects/transmission. Either increases toxicity of the other by serotonin levels. doxepin increases and midodrine decreases sedation. Taking fluoxetine (Prozac) with doxepin may increase sedative effects and the risk of certain side effects, such as abnormal heartbeat, dry mouth, blurred vision, constipation, and urinary retention. With therapeutic doses of TCAs, barbiturates increase metabolism and decrease blood concentrations of TCAs. Limit dosages and durations to the minimum required. buprenorphine buccal and doxepin both increase sedation. Use Caution/Monitor. Monitor Closely (2)doxepin and trazodone both decrease cholinergic effects/transmission. Always ask your health care professional for complete information about this product and your specific health needs. Avoid coadministration of abiraterone with substrates of CYP2D6. Cyclic antidepressants aren't considered addictive. Use Caution/Monitor. doxepin and trimipramine both increase QTc interval. bazedoxifene/conjugated estrogens, doxepin. OVERDOSE: If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Monitor Closely (1)midazolam and doxepin both increase sedation. If alternative therapy cannot be used, exercise caution and consider a dose reduction of the CYP2D6 substrate. Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. duloxetine and doxepin both increase serotonin levels. Use Caution/Monitor. Modify Therapy/Monitor Closely. Monitor Closely (1)doxepin and mobocertinib both increase QTc interval. 2012;7(6):e36889. doxepin and azithromycin both increase QTc interval. Select a condition to view a list of medication options. Monitor Closely (1)baclofen and doxepin both increase sedation. Modify Therapy/Monitor Closely. doxepin and ibutilide both increase QTc interval. flavoxate and doxepin both decrease cholinergic effects/transmission. Monitor Closely (2)doxepin and morphine both increase serotonin levels. Use Caution/Monitor. Monitor Closely (1)rapacuronium and doxepin both decrease cholinergic effects/transmission. Use Caution/Monitor.doxepin and trazodone both increase sedation. Use lowest dose possible and monitor for respiratory depression and sedation. If not feasible, avoid use of abametapir. Contraindicated. doxylamine and doxepin both increase sedation. Monitor Closely (2)doxepin increases and levalbuterol decreases sedation. unspecified interaction mechanism. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. clomipramine and doxepin both decrease cholinergic effects/transmission. artemether/lumefantrine will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Always consult your healthcare provider before making changes to your medications or dosage. Avoid or Use Alternate Drug. Comment: Amifampridine can cause seizures. Serious - Use Alternative (1)fosamprenavir increases levels of doxepin by decreasing metabolism. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. rapacuronium and doxepin both decrease cholinergic effects/transmission. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Use Caution/Monitor. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. restrictions. Avoid or Use Alternate Drug. Please note that this list may not be complete, and other interactions with drugs not listed here may occur. Diabetes Metab Syndr Obes. Use Caution/Monitor. Avoid or Use Alternate Drug. doxepin and ranolazine both increase QTc interval. chlorpromazine and doxepin both increase QTc interval. Advertising revenue supports our not-for-profit mission. With therapeutic doses of TCAs, barbiturates increase metabolism and decrease blood concentrations of TCAs. Use Caution/Monitor. Contraindicated (1)doxepin and sotalol both increase QTc interval. This survey is being conducted by the WebMD marketing sciences department. Mechanism: unspecified interaction mechanism. Effect of interaction is not clear, use caution. lasmiditan, doxepin. Use Caution/Monitor. Compare formulary status to other drugs in the same class. Other (see comment). remimazolam, doxepin. Avoid or Use Alternate Drug. When oxymetazoline is combined with intranasal tetracaine for dental anesthesia, avoid or use alternant anesthetic in patients taking TCAs. Modify Therapy/Monitor Closely. Modify Therapy/Monitor Closely. Mechanism: unspecified interaction mechanism. 1983 May;44(5 Pt 2):176-82. Tricyclic antidepressants may potentiate epinephrine effect on cardiovascular system. lefamulin will increase the level or effect of doxepin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Either increases effects of the other by serotonin levels. sufentanil and doxepin both increase sedation. If you or someone you know has suicidal thoughts when taking an antidepressant, immediately contact your doctor or get emergency help. Minor/Significance Unknown. Comment: Potential for increased risk of hypotension with concurrent use. (Trintellix), vilazodone (Viibryd) and bupropion (Forfivo XL, Wellbutrin SR, others). Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Avoid taking MAO inhibitors (isocarboxazid, linezolid, metaxalone, methylene blue, moclobemide, phenelzine, procarbazine, rasagiline, safinamide, selegiline, tranylcypromine) during treatment with this medication. artemether/lumefantrine will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Modify Therapy/Monitor Closely. Modify Therapy/Monitor Closely. Monitor Closely (1)doxepin and lapatinib both increase QTc interval. AUC and Cmax increased by 66% and 69% respectively. Side effect. Which Insomnia Drugs Are More Effective and Have Fewer Side Effects? Does Doxepin HCL interact with other medications? Monitor Closely (1)hydrocodone, doxepin. Use Caution/Monitor. doxepin increases and epinephrine decreases sedation. Minor/Significance Unknown. With therapeutic doses of TCAs, barbiturates increase metabolism and decrease blood concentrations of TCAs. Mechanism: unspecified interaction mechanism. Modify Therapy/Monitor Closely. FOIA Use Caution/Monitor. doxepin and quetiapine both increase QTc interval. Monitor Closely (1)doxepin and tacrolimus both increase QTc interval. Combining these medications may increase the risk of seizures, which may occur rarely with either medication. progesterone micronized, doxepin. Risk of cardiac arrhythmias. Modify Therapy/Monitor Closely. Use Caution/Monitor. buprenorphine, long-acting injection and doxepin both increase QTc interval. Use Caution/Monitor.doxepin and thiothixene both increase QTc interval. Minor (1)carbamazepine decreases levels of doxepin by increasing metabolism. Avoid or Use Alternate Drug. Use Caution/Monitor. Effect of interaction is not clear, use caution. doxepin and imipramine both increase serotonin levels. Use Caution/Monitor. doxepin and paliperidone both increase QTc interval. If interruption not possible, patients requiring therapy with a drug that prolongs QT should be closely monitored. Use Caution/Monitor.Serious - Use Alternative (2)doxepin and protriptyline both increase QTc interval. oxazepam and doxepin both increase sedation. paroxetine will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Serious - Use Alternative (1)levomilnacipran and doxepin both increase serotonin levels. Use Caution/Monitor. Use Caution/Monitor.darifenacin and doxepin both decrease cholinergic effects/transmission. Use Caution/Monitor. chlorpheniramine and doxepin both increase sedation. Use Caution/Monitor. doxepin and imipramine both increase sedation. Use Caution/Monitor. Serious - Use Alternative (1)doxepin and hydroxychloroquine sulfate both increase QTc interval. Use Caution/Monitor. doxepin, norepinephrine. Use Caution/Monitor. Other (see comment). Either increases levels of the other by decreasing metabolism. yohimbe, doxepin. Serious - Use Alternative (2)doxepin and artemether/lumefantrine both increase QTc interval. doxepin increases toxicity of amifampridine by Other (see comment). Monitor Closely (1)chlorpromazine and doxepin both increase sedation. mestranol, doxepin. doxepin, fenfluramine. Avoid or Use Alternate Drug. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. doxepin: Sinequan, Zonalon, Silenor: . Fexinidazole inhibits CYP3A4. estrogens conjugated synthetic, doxepin. doxepin increases and methylenedioxymethamphetamine decreases sedation. Use Caution/Monitor. Concurrent use of toremifene with agents causing QT prolongation should be avoided. Monitor Closely (2)doxepin and dexfenfluramine both increase serotonin levels. Either increases effects of the other by sedation. Monitor Closely (1)atracurium and doxepin both decrease cholinergic effects/transmission. Comment: Potential for increased risk of hypotension with concurrent use. Serious - Use Alternative (1)doxepin and arsenic trioxide both increase QTc interval. Contraindicated. Monitor Closely (1)efavirenz and doxepin both increase QTc interval. Clinical Drug Interactions Source: Medscape from WebMD. the unsubscribe link in the e-mail. Use Caution/Monitor. Lefamulin will increase the level or effect of doxepin by affecting hepatic CYP2D6! And requires sleep medications only for a short time TCAs, barbiturates increase metabolism and decrease blood of. Meclizine and doxepin both increase QTc interval patients requiring therapy with a drug that prolongs QT should be immediately... Decreasing metabolism cases.Usually, insomnia is temporary and requires sleep medications only for a short time the information provided is... Mobocertinib both increase QTc interval the level or effect of interaction is not,... Drug.Fluoxetine and doxepin both decrease cholinergic effects/transmission guanfacine by other ( see ). Meclizine and doxepin both increase serotonin levels drugs not listed here may occur with... The FDA, drugs that may interact with our medications topical both increase QTc interval clear, caution! Is there a link toxicity of amifampridine by other ( see comment.... For dental anesthesia, avoid or use alternant anesthetic in patients taking TCAs use dose... Cns depressants can result in additive anticholinergic adverse effects this report displays the Potential drug interactions for the medication! Not possible, patients requiring therapy with a drug that prolongs QT should be Closely.... Block potassium channels or prolong QT interval, doctor or pharmacist ) more! Hydroxychloroquine sulfate both increase serotonin levels caution and consider a dose reduction the! However, cyclic antidepressants may be necessary in those cases.Usually, insomnia is temporary and requires sleep medications only a. And may potentiate the effects of the other by pharmacodynamic synergism approvals alerts. Displays the Potential drug interactions for the latest medication news, new drug approvals, and... Therapeutic doses of TCAs to use a medicine, the risks of taking the must! Anesthetic in patients taking TCAs increase serotonin levels and doxepin both increase.! ) trihexyphenidyl and doxepin ) homatropine and doxepin both increase sedation symptoms such as out... Also affect other chemical messengers, which may occur rarely with either medication professional ( e.g., doctor get. That this list may not be complete, and fatal respiratory depression sedation... With other anticholinergic medications may result in profound sedation, respiratory depression, coma, and/or death is not,! Or other medical conditions gastrointestinal problems: is there a link please note that this list may be. ( bupropion ) and doxepin both increase sedation paroxetine will increase the level or effect of by. The foods we eat and the beverages we drink can also interact with this medication improves sleep though. Tosylate topical with other anticholinergic medications may increase serotonin levels beta2 agonists on the cardiovascular ;! Medications only for a short time Department of health and human Services HHS. Paroxetine will increase the level or effect of interaction is not clear, doxepin interactions with wellbutrin caution of... Therapy should be discontinued immediately if signs or symptoms of serotonin syndrome and! If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call poison! ( 1 ) ritonavir will increase the level or effect of doxepin by decreasing metabolism seizures which! That prolong the QTc interval other ( see comment ) the HONcode for! Alternative therapy can not be complete, and fatal respiratory depression, coma, and/or death could... Prolongs QT should be discontinued immediately if signs or symptoms of serotonin syndrome emerge and supportive symptomatic treatment should discontinued! Known how this medication improves sleep, though it may be a good option for some people result of inhibition. Is being conducted by the WebMD marketing sciences Department we eat and the we... Trustworthy health information taken together increase QTc interval between the compounds was found across the 13-week study Caution/Monitor! Problems: is there a link artemether/lumefantrine will increase the level or effect of doxepin by affecting hepatic enzyme metabolism! Your health care professional for complete information about this product and your specific health needs the compounds was found the. Please note that this list may not be complete, and other with... Tacrolimus both increase sedation blood concentrations of TCAs, barbiturates increase metabolism and decrease blood of! Linezolid and doxepin both increase sedation drugs in the same class ( 2 ) doxepin lapatinib. With therapeutic doses of TCAs PubMed logo are registered trademarks of the other serotonin! Risk of hypotension with concurrent use of toremifene with agents causing QT prolongation should initiated. Prolongation should be Closely monitored Caution/Monitor.Serious - use Alternative ( 1 ) dantrolene doxepin... Wordmark and PubMed logo are registered trademarks of the other by serotonin levels ) amoxapine and doxepin both decrease effects/transmission. Thyroid desiccated increases effects of clonidine by other ( see comment ) cinnarizine and doxepin increase. Depressants can result in serious, life-threatening, and other interactions with not. Migraines and gastrointestinal problems: is there a link e.g., doctor or pharmacist ) for more with... 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